Unlike osteoarthritis , which results from normal wear and tear on the joints, rheumatoid arthritis is an inflammatory condition. The exact cause of it is unknown. But it's believed to be caused by the body's immune system attacking the symposium — the tissue that lines the joints.

Rheumatoid Arthritis affects about 2.5 million Americans and about 20 million in the world. It's three times more common in women than in men and generally strikes between the ages of 20 and 50. But rheumatoid arthritis also can affect very young children and adults over age 50.

The signs and symptoms of rheumatoid arthritis may come and go over time. They include:

1) Pain and swelling in the smaller joints of your hands and feet. Overall aching or stiffness of the joints and muscles, especially after sleep or after periods of rest. Loss of motion of the affected joints, Loss of strength in muscles attached to the affected joints, Fatigue, which can be severe during a flare-up Low-grade fever Deformity of the joints as time goes on.

2) Rheumatoid arthritis usually causes problems in many joints at the same time. Joints in the wrists, hands, feet and ankles are the ones most often affected. The disease also can involve in your elbows, shoulders, hands, fingers, hips, knees, feet, ankles, heels, backbone, neck and jaw. It generally affects both sides of the body at the same time. The knuckles of both hands might be one example.

3) Small lumps, called rheumatoid nodules, may form under the skin of your elbow, your hands, the back of your scalp, over your knee or on your feet and heels. These nodules can range in size — appearing as small as a pea to as large as a walnut. Usually the lumps aren't painful.

4) In contrast to osteoarthritis, which affects only your bones and joints, rheumatoid arthritis can cause inflammation of tear glands, salivary glands, the lining of your heart and lungs, the lungs themselves and, in rare cases, your blood vessels.

5) Although rheumatoid arthritis is often a chronic disease, it tends to vary in severity and may even come and go. Periods of increased disease activity — called flare-ups or flares — alternate with periods of relative remission, during which the swelling, pain, difficulty in sleeping and weakness fade or disappear. There are many reason for these to happen in intervals, we can provide the guide line for you and each individual which will be different.

6) The flexibility of your joints may be limited by swelling or deformity. But even if you have a severe form of rheumatoid arthritis, you'll probably retain flexibility in many joints. You may also have less pain than the appearance of deformed joints suggests.

Many in our research of 145 years have shown to have history of injuries before developing RA. As with other forms of arthritis, rheumatoid arthritis involves inflammation of the joints. A membrane called the synovium lines each of your joints. When you have rheumatoid arthritis, white blood cells — whose normal job is to attack unwanted invaders such as bacteria and viruses — move from your bloodstream into your synovium. There, these blood cells appear to play an important role in causing the synovial membrane to become inflamed.

This inflammation results in the release of proteins that, over months or years, cause thickening of the synovium. These proteins also can damage cartilage, bone, tendons and ligaments. Gradually, the joint loses its shape and alignment. Eventually, it may be destroyed.

Some researchers thinks that rheumatoid arthritis is triggered by an infection — possibly a virus or bacterium — in people with an inherited susceptibility. Although the disease itself is not inherited, certain genes that create a susceptibility are. People who have inherited these genes will not necessarily develop rheumatoid arthritis. But they may have more of a tendency to do so than others. The severity of their disease may also depend on the genes inherited.

See your doctor if you have persistent discomfort and swelling in multiple joints on both sides of your body. Also seek medical advice if you experience side effects from arthritis medications which a lot of the patients have, like stomach discomfort, black or tarry stools, changes in bowel habits, constipation, internal bleeding, kidney damage, liver damage, dizziness, or nausea.

Rheumatoid arthritis symptoms, your doctor will likely conduct a physical examination, it may be easy for a doctor to identified R.A. Beside that, laboratory tests also can determine if you have this form of arthritis. A blood test that indicates your erythrocyte sedimentation rate ("sed" rate) can indicate the presence of an inflammatory process in your body. People with rheumatoid arthritis tend to have abnormally high sed rates. The sed rates in those with osteoarthritis tend to be normal.

Another blood test looks for an antibody called rheumatoid factor. Four out of five persons with rheumatoid arthritis eventually have this abnormal antibody, although it may be absent early on in the disease. It's also possible to have the rheumatoid factor in your blood and not have rheumatoid arthritis.

Doctors may take X-rays of your joints to differentiate between osteoarthritis and rheumatoid arthritis. A sequence of X-rays obtained over time can show the progression of arthritis. These may not be necessary.

Rheumatoid arthritis causes pain and may also cause fatigue and stiffness. It can lead to difficulty with everyday tasks, such as turning a doorknob or holding a pen. Dealing with the pain and unpredictability of rheumatoid arthritis can also cause depression and bedridden.

In the past, people with rheumatoid arthritis may have ended up confined to a wheelchair because damage on joints made it difficult or impossible to walk.

Treating rheumatoid arthritis typically involves using a combination of medical treatment and self-care strategies. The following self-care procedures are important elements for managing the disease.

1) Exercise regularly. Different types of exercise achieve different goals. If you can walk, walking is a good starter exercise. If you can't walk, try a stationary bicycle with no resistance or do hand or arm exercise. A chair exercise program may be helpful. Aquatic exercise is another option, and many health clubs with pools offer such classes.

2) It's good to move each joint in its full range of motion every day. As you move, maintain a slow, steady rhythm. Don't jerk or bounce. Also, remember to breathe. Holding your breath can temporarily deprive your muscles of oxygen and tired them. It's also important to maintain good posture while you exercise. Avoid exercising tender, injured or severely inflamed joints. If you feel new joint pain, stop. New pain that lasts more than 2 hours after you exercise probably means you've overdone it. If pain persists for more than a few days, call your doctor.

3) Control your weight. Excess weight puts added stress on joints in your neck, hips, knees and feet — places where arthritis pain is commonly felt. Excess weight can also make joint surgery more difficult and risky. Eat a healthy diet. A healthy diet emphasizing fruit, vegetables and whole grains can help you control your weight and maintain your overall health, allowing you to deal better with your arthritis. However, there is no special diet that can be used to treat arthritis. It hasn't been proven that eating any particular food will make your joint pain or inflammation better or worse.

4) Apply heat. Heat will help ease your pain, relax tense, painful muscles and increase the regional flow of blood. One of the easiest and most effective ways to apply heat is to take a hot shower or bath for 15 minutes. Other options include using a hot pack, an electric heat pad (set on its lowest setting) or a radiant heat lamp with a 250-watt reflector heat bulb to warm specific muscles and joints. If your skin has poor sensation or if you have poor circulation, don't use heat treatment.

Coping Skills The degree to which rheumatoid arthritis affects your daily activities depends in part on how well you cope with the disease. Physical and occupational therapists can help you devise strategies to cope with specific limitations you experience as the result of weakness or pain. Here are some general suggestions to help you cope:

- Keep a positive attitude. With our advise, we make a plan for managing your arthritis. This will help you feel in charge of your disease. Studies show that people who take control of their treatment and actively manage their arthritis experience less pain and have less difficulty functioning.

- Use assertive devices. A painful knee may need a brace for support. You also might want to use a cane to take weight off the joint as you walk. The cane should be used in the hand opposite the affected joint. If your hands are affected, various helpful tools and gadgets are available to help you maintain an active lifestyle. Contact your pharmacy or health care provider for information on ordering items that may help you the most.

- Know your limits. Rest when you're tired. Arthritis can make you prone to fatigue and muscle weakness — a deep exhaustion that makes everything you do a great effort. A rest or short nap that doesn't interfere with nighttime sleep may help.

- Avoid grasping actions that strain your finger joints. Instead of using a clutch purse, for example, select one with a shoulder strap. Use hot water to loosen a jar lid and pressure from your palm to open it, or use a jar opener. Don't twist or use your joints forcefully. Spread the weight of an object over several joints. For instance, use both hands to lift a heavy pan.

Take a break periodically to relax and stretch. Maintain good posture. Poor posture causes uneven weight distribution and may strain ligaments and muscles. The easiest way to improve your posture is by walking. Some people find that swimming also helps improve their posture. Use your strongest muscles and favor large joints. Don't push open a heavy glass door. Lean into it. To pick up an object, bend your knees and squat while keeping your back straight.