Creatinine is a metabolic product produced by creatine and phosphocreatin in muscle and its daily production is constant. Little creatinine is produced from meat -based foods obtained from the daily diet. Creatinine is carried through the blood to the kidneys. The kidneys filter out creatinine and excrete it in the urine.

The clearing creatinine test measures the amount of creatinine that has been excreted from the blood into the urine over a 24 -hour period.

How To Use

The clearans creatinine test was used to estimate the glomerular filtration rate. The glomerular filtration rate is a measure to determine the ability of the kidneys to function, especially the filter unit. This filter unit is called the glomeruli.

Creatinine is excreted from the body through the kidneys. If the bowel does not function normally, the level of creatinine in the blood will increase because less creatinine is excreted through the urine.

Tests Performed in the Laboratory

The laboratory will measure the volume of urine collected 24 hours a day, as well as the creatinine level from the blood sample and the creatinine level from the urine sample. Calculations will be made as a result of the results obtained.

Creatinine clearans is expressed in units of ml/min.

Calculation of Creatinine clearing

= Creatinine level from urine x 24 -hour urine volume (ml)

Creatinine level from blood x (24 hours x 60 minutes)

Samples are required

This test requires the collection of urine for a period of 24 hours and one blood sample taken during the period of urine collection.

Patient preparation

Patient Preparation
  1. Avoid taking medications that can interfere with test results. Drugs that can increase creatinine levels in the blood and in turn lower clearans creatinine levels include Cephalosporin, Aminoglycoside, Flucytosine, Cisplatin, Cimetidine and Trimethoprim.

  2. If possible, the drug should be stopped first.

  3. Make sure the patient drinks enough water before urine collection is started.

  4. Recommended intake of non -meat based diet.

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